Figure S4 from Combination of TMB and CNA Stratifies Prognostic and Predictive Responses to Immunotherapy Across Metastatic Cancer

Sensitivity analysis of overall survival (OS) or progression-free survival (PFS) in three cohorts treated with immune checkpoint inhibitor (ICI) by altering cut-point (median, tertile, quartile) of TMB and CNA. (A) Univariate analysis of treatment survival in three ICI treated cohorts with different cut-points (median, tertile, quartile) of TMB and CNA. (B-D) Multivariate analysis of treatment survival in three ICI treated cohorts with the inclusion of alternate cut-points of CNA and TMB, and illustrated in three groups stratified by the cut-points of CNA (B: {greater than or equal to}median vs