Control of Macrophage Activation and Function by PPARs

Macrophage,a key component of the innate defense against pathogens,participates in the initiation and resolution of inflammation,and in the maintenance of tissues.These diverse functions of macrophages are executed via distinct activation states,ranging from classical to alternative to deactivation.The dysregulation of macrophage activation is pathogenically linked to various metabolic,inflammatory and immune disorders.Regulatory proteins controlling macrophage activation have emerged as important new therapeutic targets.Here,the mechanisms by which peroxisome proliferator-activated receptors(PPARs) transcriptionally regulate macrophage activation in disease states are reviewed.