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Disruption of the TP53 Locus in Osteosarcoma Leads to TP53 Promoter Gene Fusions and Restoration of Parts of the TP53 Signalling Pathway.

Karim H. Saba,Valeria Difilippo,Michal Kovac,Louise Cornmark,Linda Magnusson,Jenny Nilsson,Hilda van den Bos,Diana C. J. Spierings,Mahtab Bidgoli,Tord Jonson,Vaiyapuri P. Sumathi, Otte Brosjoe,Johan Staaf,Floris Foijer,Emelie Styring,Michaela Nathrath,Daniel Baumhoer,Karolin H. Nord

JOURNAL OF PATHOLOGY（2024）

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Key words
osteosarcoma,promoter swapping,TP53 promoter,TP53 intron 1,separation-of-function mutation,TP53 signalling pathway,p53,TP53 mutation,gene fusion
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