谷歌浏览器插件
订阅小程序
在清言上使用

Prognosis after Heart Transplant in Patients with Hypertrophic and Restrictive Cardiomyopathy. A Nationwide Registry Analysis.

REVISTA ESPANOLA DE CARDIOLOGIA(2024)

引用 0|浏览15
暂无评分
摘要
Introduction and objectives: Posttransplant outcomes among recipients with a diagnosis of hypertrophic cardiomyopathy (HCM) or restrictive cardiomyopathy (RCM) remain controversial. Methods: Retrospective analysis of a nationwide registry of first-time recipients undergoing isolated heart transplant between 1984 and 2021. One-year and 5-year mortality in recipients with HCM and RCM were compared with those with dilated cardiomyopathy (DCM). Results: We included 3703 patients (3112 DCM; 331 HCM; 260 RCM) with a median follow-up of 5.0 [3.1-5.0] years. Compared with DCM, the adjusted 1-year mortality risk was: HCM: HR, 1.38; 95%CI, 1.07-1.78; P = .01, RCM: HR, 1.48; 95%CI, 1.14-1.93; P = .003. The adjusted 5-year mortality risk was: HCM: HR, 1.17; 95%CI, 0.93-1.47; P = .18; RCM: HR, 1.52; 95%CI, 1.22-1.89; P < .001. Over the last 20 years, the RCM group showed significant improvement in 1-year survival (adjusted R-2 = 0.95) and 5-year survival (R-2 = 0.88); the HCM group showed enhanced the 5-year survival (R-2 = 0.59), but the 1-year survival remained stable (R-2 = 0.16). Conclusions: Both RCM and HCM were linked to a less favorable early posttransplant prognosis compared with DCM. However, at the 5-year mark, this unfavorable difference was evident only for RCM. Notably, a substantial temporal enhancement in both early and late mortality was observed for RCM, while for HCM, this improvement was mainly evident in late mortality. (c) 2023 Sociedad Espanola de Cardiologia. Published by Elsevier Espana, S.L.U. All rights reserved.
更多
查看译文
关键词
Cardiomyopathy restrictive,Hypertrophic cardiomyopathy,Heart transplantation,Prognosis
AI 理解论文
溯源树
样例
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要