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BRCA1/BRCA2-Associated Pancreatic Cancer: Case Series

Vera Polyakova,Natalia Bodunova,Igor Khatkov, Polina Feoktistova, Elena Kolyago, Paul Agami,Magomet Baychorov,Tatiana Yanova

BIONANOSCIENCE(2024)

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Abstract
The presence of a mutation in the BRCA1/2 genes makes it possible to use platinum drugs and PARP inhibitors in patients with pancreatic cancer. Conducting molecular genetic testing allows you to assess the risk of developing malignant neoplasms in a patient and his relatives. We present a series of clinical cases of patients with pancreatic cancer associated with BRCA 1/2. Conducting molecular genetic testing allows you to assess the risk of developing malignant neoplasms in a patient and his relatives. A burdened family history is an indication for molecular genetic diagnosis to identify a pathogenic variant and the possibility of prescribing observation to detect a malignant neoplasm at an early stage.
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Key words
BRCA1/BRCA2 mutation,Pancreatic cancer,Treatment
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