O -Glcnac Regulates YTHDF1 and YTHDF3 Activity

YTHDF family members are ‘readers’ of a common mRNA modification, but their effects on mRNA translation and stability have been disputed. A new study shows that YTHDF1 and YTHDF3 are post-translationally regulated through O -GlcNAcylation, unifying disparate results and pointing to environmental cues that could modulate YTHDF function.