Research on Promoting the Asymmetric Reaction of Phenylacetylene with Aldehydes by Chloramphenicol Base Ligands.

A series of chiral ligands were synthesized using chloramphenicol base as starting materials. These ligands were applied to the asymmetric catalytic reactions of terminal alkynes with aldehydes to obtain a propargyl alcohol product in high yield (80-94%) with excellent enantioselectivities (82-96%). The (1S, 2S)-1-phenyl-2-(1-piperidyl)-1,3-propanediol ligand was applied to the asymmetric catalytic reactions of terminal alkynes with aldehydes to obtain a propargyl alcohol product in high yield (80-94%) with excellent enantioselectivities (82-96%).image