Discovery of a Potent and Selective PARP1 Degrader Promoting Cell Cycle Arrest Via Intercepting CDC25C-CDK1 Axis for Treating Triple-Negative Breast Cancer.

Yiquan Wu,Mingfei Wu,Xiaoli Zheng,Hengyuan Yu, Xinfei Mao,Yuyuan Jin,Yanhong Wang,Ao Pang,Jingyu Zhang,Shenxin Zeng,Tengfei Xu,Yong Chen,Bo Zhang,Nengming Lin,Haibin Dai,Yuwei Wang,Xiaojun Yao,Xiaowu Dong,Wenhai Huang,Jinxin Che

BIOORGANIC CHEMISTRY（2024）

引用 0|浏览29

暂无评分

关键词

PROTACs,PARP1,DNA lesion,CDC25C-CDK1 axis,Cycle arrest,Triple-negative breast cancer

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要