LB1720 Genome-wide Association Study of Rosacea Finds Enrichment in Immune-Related Genes

Rosacea is a common inflammatory skin condition that affects as many as 415 million worldwide and primarily manifests as reddening (flushing) on different parts of the face. First classification of rosacea splits it into four distinct subtypes depending on the location and symptoms of the affected areas; however, many individuals experience multiple subtypes together. While research has implicated a range of biological systems and risk factors, the etiology of rosacea remains poorly understood. In this study, we used the UK Biobank, a large well-phenotyped population database, to run a case-control genome-wide association study (GWAS) of rosacea (Ncases = 9,405 and Ncontrol = 158,113) to better understand the biological mechanism that may be affecting rosacea.