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Robust Production of Monovalent Bispecific IgG Antibodies Through Novel Electrostatic Steering Mutations at the CH1-Cλ Interface

John D. Bagert,Vaheh Oganesyan, Chi- Chiang, Mike Iannotti,Jia Lin,Chunning Yang, Sterling Payne, Will McMahon,Samuel Edwards,Andrew Dippel,Mark Hutchinson,Fengying Huang,Vineela Aleti,Chendi Niu,Chen Qian, Jessica Denham,Sofia Ferreira,Pallab Pradhan,Mark Penney,Chunlei Wang,Wenhai Liu,Even Walseng,Yariv Mazor

doaj（2023）

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关键词
Antibody,bispecific,chain,charge,electrostatic,engineering,DuetMab,lambda,pairing,steering
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