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RNA Aptamer Reveals Nuclear TDP-43 Pathology is an Early Aggregation Event That Coincides with STMN-2 Cryptic Splicing and Precedes Clinical Manifestation in ALS

Holly Spence,Fergal M. Waldron,Rebecca S. Saleeb,Anna-Leigh Brown,Olivia M. Rifai,Martina Gilodi, Fiona Read, Kristine Roberts,Gillian Milne,Debbie Wilkinson,Judi O’Shaughnessy,Annalisa Pastore,Pietro Fratta,Neil Shneider,Gian Gaetano Tartaglia,Elsa Zacco,Mathew H. Horrocks,Jenna M. Gregory

ACTA NEUROPATHOLOGICA（2024）

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关键词
TDP-43,Loss-of-function,Neuropathology,Cryptic splicing,Stathmin-2,RNA aptamer,Amyotrophic lateral sclerosis,Cognition
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