Safety and Efficacy of Botulinum toxin Toxin A combined with Radiofrequency Home- Device for Rejuvenation

Abstract Botulinum toxin type A (BoNT-A) is confirmed to be effective and one of the most widely used cosmetic injection techniques for treating dynamic wrinkles. In principle, it has been proven to reduce wrinkles by inhibiting the release of acetylcholine from presynaptic nerve endings, causing chemical denervation and resultant muscle paresis [1-3]. To maintain the effects continuously, continuous injections at regular intervals are required because the neuronal and muscular changes that occur after BoNT-A administration are completely reversible, and the duration of maintenance is limited [4]. Furthermore, it can only improve dynamic wrinkles, not wrinkles and lines that have already formed. In recent times, many studies have reported clinical benefits of radiofrequency (RF) home-use devices in reducing wrinkles on the skin by heating dermal tissue and firming collagen fibers[5-7]. These devices are highly suitable for daily skincare maintenance or for prolonging the duration of results after undergoing aesthetic procedures, with their safety and efficacy well-established [8, 9].In this study, we aimed to assess the safety and efficacy of home-use RF device combined with botulinum toxin A treatment for periocular wrinkles.