Prognostic Impact of Venous Thromboembolism on the Course of Sarcoidosis: A Multicenter Retrospective Case-Control Study

Dov Taieb,Jean Pastre,Karine Juvin,Diane Bouvry,Florence Jeny,Olivier Sanchez,Yurdagul Uzunhan,Dominique Valeyre,Hilario Nunes,Dominique Israel-Biet

RESPIRATORY MEDICINE AND RESEARCH（2023）

Service de Pneumologie et Soins Intensifs | Hop Avicenne | Univ Sorbonne Paris Nord | Univ Paris Cite

Cited 2|Views32

Abstract

Sarcoidosis is an independent risk factor for venous thromboembolism (VTE). However, the characteristics and clinical evolution of sarcoidosis patients presenting a VTE (sarcoidosis/VTE group) in the course of their disease are not known. Consequently, if VTE occurrence is associated with a more severe disease is still pending.We conducted a retrospective case-control study of sarcoidosis/VTE patients compared to matched sarcoidosis controls without VTE in two French tertiary centers, analysed and compared the clinical, biological, functional, imaging and evolutive profiles of the two groups.Sixty-one patients were included with at least one episode of VTE during course of sarcoidosis. At sarcoidosis onset (before/at the time of VTE occurrence) the number of affected organs, radiological stages and pulmonary functional tests were not significantly different between the two groups. In contrast, we found that sarcoidosis/VTE patients required more frequently a systemic immunosuppressive therapy (corticosteroids and/or immunosuppressors, 79% versus 58%; p = 0.008). The functional course was also poorer in sarcoidosis/VTE patients with a more frequent decrease in functional vital capacity (33% versus 18% in sarcoidosis/VTE patients and controls, respectively, p = 0.008). Finally, sarcoidosis/VTE patients presented more frequently with pulmonary hypertension (10% versus 1% in patients and controls, respectively, p = 0.006), and their survival was significantly worse (log-rank p <0.001).The occurrence of VTE during sarcoidosis is associated with a more severe disease and a poorer prognosis. The occurrence of VTE during sarcoidosis might signal a more inflammatory and/or evolutive disease in sarcoidosis/VTE patients and should be taken in consideration when designing therapeutic strategies for them.(c) 2023 SPLF and Elsevier Masson SAS. All rights reserved.

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Key words

Sarcoidosis,Venous thromboembolism,In flammation,Coagulation

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