Molecular Mechanism of Α-Synuclein Aggregation on Lipid Membranes Revealed

Alexander J. Dear,Xiangyu Teng,Sarah R. Ball, Joshua Lewin,Robert I. Horne, Daniel Clow, Alisdair Stevenson, Natasha Harper, Kim Yahya,Xiaoting Yang, Suzanne C. Brewerton,John Thomson,Thomas C. T. Michaels,Sara Linse,Tuomas P. J. Knowles,Johnny Habchi,Georg Meisl

Chemical science（2024）

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摘要

Lipids are an important factor in the disease-associated aggregation of α-synuclein. Here we develop a kinetic model that allows the determination of mechanistic details and rate constants of this process.

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