A Novel Nanobody-Based HER2-targeting Antibody Exhibits Potent Synergistic Antitumor Efficacy in Trastuzumab-Resistant Cancer Cells

Xinlin Liu,Linli Luan, Xi Liu,Dingwen Jiang,Junwen Deng,Jiazhen Xu,Yang Yuan,Jiyao Xing, Bingguan Chen,Dongming Xing,Haiming Huang

Frontiers in immunology（2023）

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关键词
HER2,nanobody,Fc fusion,trastuzumab-resistance,synergistic efficacy,ligand-dependent heterodimerization
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