Identification of novel targets and mechanisms of wogonin on lung cancer, bladder cancer, and colon cancer

•WOG suppresses cancers via regulating arachidonic acid, Ras, MAPK, linoleic acid, PI3K-Akt, folate biosynthesis pathways.•WOG inhibits the proliferation of A549 cells through regulating 18 targets, including AKR1B10, AKR1C3, BDNF, CAV1, CXCL2, CYP2B6, CYP4F3, DAO, EGF, ENO3, IL6, PLA2G1B, PLA2G2F, PLA2G4A, PTGES, SLCO1B1, SLCO1B3, and TFAP2A.•By suppressing BDNF, FGF2, and PTGS1, WOG alleviates proliferation and invasion of BLCA.•WOG suppresses the expression of NTF4 and TH, resulting in the activation of autophagy pathway and inhibition of proliferation and EMT to alleviate COAD.