The Significant Role of a Functional Polymorphism Rs9637231 in Long Non-Coding RNA, LINC02892 in Colorectal Cancer: Evidence from an Iranian Cohort

Background: Long noncoding RNAs (lncRNAs) are known to be involved in cancer development and progression. Single nucleotide polymorphisms (SNPs) in lncRNAs may affect the structure, expression, and function of lncRNAs, influencing the cancer risk. In the present case-control study, we investigated the association of LINC02892 SNP rs963723l with colorectal cancer (CRC). Methods: A total of 1130 samples (530 cases and 600 controls), were collected to determine the association between rs9637231 C > T and CRC. Tetra Primer ARMS-PCR was used to determine the genotypes. Statistical analysis was performed employing logistic regression. Results: The analysis results indicated that individuals with TT genotype had 89% (95%CI = 1.40-2.57, P < 1.00E-3) and 53% (OR = 1.53, 95%CI = 1.12-2.1, P = 8.00E-3) higher risks of CRC compared to wild-type homozygotes and C allele carriers, respectively. Furthermore, T allele carriers demonstrated a 72% (OR = 1.72, 95%CI = 1.31-2.25, P < 0.001) increased risk of CRC in comparison with wild-type homozygotes. The outcomes were adjusted for factors such as age, gender, and smoking status. Conclusions: SNP rs9637231 might be a risk factor for CRC.