Similarities and differences in gene expression profiles of BRCA1 methylated and mutated epithelial ovarian cancers.

Nora Sahnane,Laura Libera,Sofia Facchi,Ileana Carnevali,Susanna Ronchi,Chiara Albeni,Antonella Cromi,Jvan Casarin,Fausto Sessa,Maria Grazia Tibiletti

Frontiers in oncology（2023）

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摘要

In conclusion, even if the expression profile of many genes related to DNA damage and repair system is shared between and EOCs supporting that EOCs may benefit from PARPi therapies, our data demonstrate that and EOCs show different expression profiles, suggesting a different mechanism of carcinogenesis that can be reflected in different responses to therapies and disease recovery.

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关键词

BRCA1 methylation, NanoString (R), gene expression profiles, PARPi therapy, EOC

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