Teriflunomide and Epstein-Barr virus in a Spanish multiple sclerosis cohort: in vivo antiviral activity and clinical response.

María Inmaculada Domínguez-Mozo,Inés González-Suárez,Luisa María Villar,Lucienne Costa-Frossard,Noelia Villarrubia,Yolanda Aladro,Belén Pilo,Xavier Montalbán,Manuel Comabella,Ignacio Casanova-Peño,María Luisa Martínez-Ginés,Jose Manuel García-Domínguez,María Ángel García-Martínez,Rafael Arroyo,Roberto Álvarez-Lafuente

Frontiers in immunology（2023）

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摘要

Treatment with teriflunomide was associated with a reduction of the levels of IgG antibody titers against EBV and HHV-6. Furthermore, higher EBNA-1 IgG titers prior to teriflunomide initiation were associated with a better clinical response.

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关键词

multiple sclerosis, teriflunomide, biomarker, EDSS, EBV, HHV-6, NF-L, ELISA

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