Circulating cell-free mtDNA as a new biomarker for cancer detection and management

Cancer is a major cause of death worldwide, and was respon-sible for 19.29 million new cases and 9.96 million deaths in 2020 alone. The total number of patients with cancer world-wide is estimated to reach 28 million by 2040. The American Association for Cancer Research has also estimated approxi-mately 16.2 million cancer deaths by 20401.