Knockdown of Angiopoietin-Like 4 Suppresses Sepsis-Induced Acute Lung Injury by Blocking the NF-κB Pathway Activation and Hindering Macrophage M1 Polarization and Pyroptosis

•Knockdown of ANGPTL4 ameliorates sepsis-induced ALI in mice.•ANGPTL4 silencing represses BALF macrophage M1 polarization in sepsis-induced ALI.•Knockdown of ANGPTL4 restrains macrophage pyroptosis in sepsis-induced ALI.•ANGPTL4 knockout impedes LPS-induced M1 macrophage polarization and pyroptosis.•ANGPTL4 knockout hinders LPS-induced the NF-κB pathway activation in macrophages.