Zinc-sensitive MRI Contrast Agents: Importance of Local Probe Accumulation in Zinc-Rich Tissues.

Kyangwi P. Malikidogo,Manon Isaac, Adrien Uguen,Sandra Meme,Agnes Pallier,Rudy Clemencon,Jean-Francois Morfin,Sara Lacerda,Eva Toth,Celia S. Bonnet

CHEMICAL COMMUNICATIONS（2023）

Cited 0|Views21

No score

Abstract

We present the in vitro characterisation of a Gd3+-based contrast agent that responds to Zn2+ upon interaction with Human Serum Albumin. We show that the contradictory in vivo behaviour is related to Gd3+-accumulation in Zn-rich tissues. This highlights the importance of the biodistribution of such contrast agents.

Translated text

Key words

MRI Contrast Agents,Zinc

AI Read Science

Must-Reading Tree

Example

Generate MRT to find the research sequence of this paper

Chat Paper

Summary is being generated by the instructions you defined