Exploring the Influence of Parametrized Pulsatility on Left Ventricular Washout under LVAD Support: A Computational Study Using Reduced-Order Models
arXiv (Cornell University)(2023)
摘要
Medical therapy for patients with severe heart disease often relies on left
ventricular assist devices (LVADs). It is an ongoing topic of research how
complications like stagnation and thrombosis can be prevented by using
artificial pulsatility. We study a parametric pulse profile and its effect on
the left ventricular washout using a computational flow model. Based on finite
element simulations, we construct reduced-order models to reduce the
computational costs for evaluating the parametrized problem. We observe that a
pulsatile flow rate improves the washout compared to a constant flow rate. In
particular, we find that short, intense pulses wash out the left ventricle
best, whereas the time between subsequent pulses plays no significant role.
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关键词
left ventricular
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