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Structure-Based Design and Synthesis of Potent and Selective KRAS G12D Inhibitors

Hengmiao Cheng, Puhui Li, Ping Chen,Adriana Irimia,Jae Hyun Bae,Alexei Brooun,Patrick Fagan,Richard Lam,Bingzhen Lin,Jingchuan Zhang, Xuejun Zhan, Xu Wu,Nan Xie, Gary Chiang,Robert Shoemaker, Jean-Michel Vernier

ACS medicinal chemistry letters（2023）

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关键词
KRAS,G12D selective inhibitor,ERAS-5024,SBDD,PDAC,anti-tumor efficacy
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