Tonic-signaling chimeric antigen receptors drive human regulatory T cell exhaustion

Caroline Lamarche,Kirsten Ward-Hartstonge,Tian Mi,David T. S. Lin,Qing Huang,Andrew Brown,Karlie Edwards,Gherman E. Novakovsky,Christopher N. Qi,Michael S. Kobor,Caitlin C. Zebley,Evan W. Weber,Crystal L. Mackall,Megan K. Levings

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA（2023）

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regulatory T cells, exhaustion, tolerance, chimeric antigen receptor, epigenetics

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