Characterization of DNA Damage Response-Associated Somatic Mutations in Borderline Resectable and Locally Advanced Pancreatic Cancer

V. Madan,T. A. Lin,A. V. Reddy, C. Hill,S. Sehgal,A. Hacker-Prietz, T. McPhaul, J. He, L. Zheng, W. Ngwa,J. M. Herman,J. J. Meyer,A. Narang

International journal of radiation oncology, biology, physics（2023）

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摘要

Herein, we characterized the frequency of somatic mutations associated with DSB repair genes in patients with BRPC/LAPC. Data analysis on outcomes related to radiation response in patients with mutations in DDR pathways is ongoing, but will likely also benefit from multi-institutional efforts to increase the power to answer this question.

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