Prognostic Value of Hypoxia Gene Expression Signature in Early-Stage Non -Small Cell Lung Cancer Patients Treated with Stereotactic Body Radiation Therapy

Our findings demonstrate that a hypoxia gene signature is significantly associated with worse survival and increased local and distant recurrence after SBRT for localized NSCLC. This hypoxia signature may be useful in prognostication, selecting patients for surgery versus radiation, or selecting patients for treatment intensification with radiation or other systemic agents, and should be prospectively validated.