Clinical Outcomes Following an Initial Stereotactic Radiosurgery Course for Brain Metastases from Melanoma

J. X. Leng, C. C. Huang, J. J. Qazi,D. J. Carpenter, B. D. Natarajan,M. Arshad,M. Ferreira, O. Schultz,M. J. Moravan, T. C. Mullikin,Z. J. Reitman,J. P. Kirkpatrick,S. R. Floyd,A. K. S. Salama, P. Fecci,S. J. Chmura, J. C. Hong,J. K. Salama

International journal of radiation oncology, biology, physics（2023）

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摘要

In this modern, multi-institutional cohort of SRS patients, melanoma BM patients had worse FFICP compared to non-melanoma BM patients, and BRAFmut patients had worse FFICP than BRAFwt patients. RN was associated with mutational status and receipt of TT pre-SRS. OS did not vary significantly across groups. This analysis may help inform systemic therapy decisions and future genomic studies for patients with BMs from melanoma.

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关键词

stereotactic radiosurgery,initial stereotactic radiosurgery course,brain metastases,melanoma,clinical outcomes

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