Discovery of a cystathionine γ -lyase (CSE) selective inhibitor targeting active-site pyridoxal 5′-phosphate (PLP) via Schiff base formation

Honami Echizen,Kenjiro Hanaoka,Kazuhito Shimamoto,Ryota Hibi,Sachiko Toma-Fukai,Hisashi Ohno,Eita Sasaki,Toru Komatsu,Tasuku Ueno,Yukihiro Tsuchiya,Yasuo Watanabe,Takao Otsuka,Hiroaki Saito,Satoru Nagatoishi,Kouhei Tsumoto,Hirotatsu Kojima,Takayoshi Okabe,Toshiyuki Shimizu,Yasuteru Urano

Scientific reports（2023）

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Key words

Chemical libraries,Chemical tools,Drug screening,Enzyme mechanisms,Science,Humanities and Social Sciences,multidisciplinary

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