A Human Genome Editing-Based MLL::AF4 ALL Model Recapitulates Key Cellular and Molecular Leukemogenic Features

Blood（2023）

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摘要

Cellular ontogeny and MLL breakpoint site influence the capacity of MLL-edited CD34+ hematopoietic cells to initiate and recapitulate infant patients' features in pro-B-cell acute lymphoblastic leukemia (B-ALL). We provide key insights into the leukemogenic determinants of MLL-AF4+ infant B-ALL.

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Hematopoietic Progenitor Cells

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