Effect of Melatonin on Alpha Synuclein and Autophagy in Dopaminergic Neuronal Differentiation of Adipose Mesenchymal Stem Cells.

Hadeer Ahmed Mohamed Ibrahim,Abdelaziz Mohamed Hussein,Mahmoud Gabr,Rasha Aly El-Saeed,Omar Abd-Alhakem Ammar, Ahmed Abdulatif Hassan Mosa,Abdel-Aziz Fatouh Abdel-Aziz

Reports of biochemistry & molecular biology（2023）

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摘要

It is concluded that the melatonin promotes the differentiation of rat AD-MSCs into dopaminergic cells via induction of autophagy process and reduction of α-Syn secretion.

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关键词

adipose mesenchymal stem cells,melatonin,dopaminergic neuronal differentiation,alpha synuclein,mesenchymal stem cells

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