Plasma Protein Binding Determination for Unstable Ester Prodrugs: Remdesivir and Tenofovir Alafenamide.

Anita Wen,Ann Ran-Ran Qin,Thomas Tarnowski,Kah Hiing John Ling,Haeyoung Zhang,Rita Humeniuk, Sean Regan, Jovita Saquing,Wenbin Liu,Lata Venkatarangan,Deqing Xiao

Journal of Pharmaceutical Sciences（2023）

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关键词

Protein binding,Plasma,Equilibrium dialysis,Ultra filtration,Esterase inhibitor,Dichlorvos,Fit for purpose,Prodrug,Remdesivir (RDV),Tenofovir alafenamide (TAF)

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