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SPIOMET4HEALTH-efficacy, Tolerability and Safety of Lifestyle Intervention Plus a Fixed Dose Combination of Spironolactone, Pioglitazone and Metformin (SPIOMET) for Adolescent Girls and Young Women with Polycystic Ovary Syndrome: Study Protocol for a Multicentre, Randomised, Double-Blind, Placebo-Controlled, Four-Arm, Parallel-Group, Phase II Clinical Trial.

Cristina Garcia-Beltran,Rita Malpique,Marianne S. Andersen,Firdevs Bas,Judit Bassols,Feyza Darendeliler,Marta Díaz,Barbara Dieris,Flaminia Fanelli,Elke Fröhlich-Reiterer,Alessandra Gambineri,Dorte Glintborg,Abel López-Bermejo, Christopher Mann,Silvia Marin,Barbara Obermayer-Pietsch,Rønnaug Ødegård,Pernille Ravn,Thomas Reinehr,Matteo Renzulli,Cristina Salvador,Viola Singer,Eszter Vanky,Juan Vicente Torres,Melek Yildiz,Francis de Zegher,Lourdes Ibáñez

Trials（2023）

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Key words
Androgen excess,Polycystic ovary syndrome,PCOS,Ectopic fat,Liver fat,Central obesity,Anovulation,Pioglitazone,Spironolactone,Metformin
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