Chrome Extension
WeChat Mini Program
Use on ChatGLM

Effects of Red Blood Cell Transfusion on Patients Undergoing Cardiac Surgery in Queensland – a Retrospective Cohort Study

Heart Lung and Circulation(2023)

Critical Care Research Group

Cited 0|Views11
Abstract
Background Packed red blood cell (pRBC) transfusion is a relatively safe and mainstay treatment commonly used in cardiac surgical patients. However, there is limited evidence on clinical effects of transfusing blood nearing end-of shelf life that has undergone biochemical changes during storage. Objective To investigate evidence of associations between morbidity/mortality and transfusion of blood near end of shelf-life (>35 days) in cardiac surgical patients. Methods Data from the Queensland Health Admitted Patient Data Collection database 2007-2013 was retrospectively analysed. Coronary artery bypass graft and valvular repair patients were included. Multivariable logistic regression was used to examine the effect of pRBC age (<35 days vs ≥35 days) on in-hospital mortality and morbidity. As secondary analysis, outcomes associated with the number of pRBC units transfused (≤4 units vs ≥5 units) were also assessed. Results A total of 4514 cardiac surgery patients received pRBC transfusion. Of these, 292 (6.5%) received pRBCs ≥35 days. No difference in in-hospital mortality or frequency of complications was observed. Transfusion of ≥5 units of pRBCs compared to the ≤4 units was associated with higher rates of in-hospital mortality (5.6% vs 1.3%), acute renal failure (17.6% vs 8%), infection (10% vs 3.4%), and acute myocardial infarction (9.2% vs 4.3%). Infection carried an odds ratio of 1.37 between groups (CI=0.9-2.09; p=0.14) and stroke/neurological complications, 1.59 (CI=0.96-2.63; p=0.07). Conclusion In cardiac surgery patients, transfusion of pRBCs closer to end of shelf-life was not shown to be associated with significantly increased mortality or morbidity. Dose-dependent differences in adverse outcomes (particularly where units transfused were >4) were supported.
More
Translated text
Key words
Red blood cell transfusion,Cardiac surgery,Age of packed red blood cells,Storage lesion
PDF
Bibtex
AI Read Science
AI Summary
AI Summary is the key point extracted automatically understanding the full text of the paper, including the background, methods, results, conclusions, icons and other key content, so that you can get the outline of the paper at a glance.
Example
Background
Key content
Introduction
Methods
Results
Related work
Fund
Key content
  • Pretraining has recently greatly promoted the development of natural language processing (NLP)
  • We show that M6 outperforms the baselines in multimodal downstream tasks, and the large M6 with 10 parameters can reach a better performance
  • We propose a method called M6 that is able to process information of multiple modalities and perform both single-modal and cross-modal understanding and generation
  • The model is scaled to large model with 10 billion parameters with sophisticated deployment, and the 10 -parameter M6-large is the largest pretrained model in Chinese
  • Experimental results show that our proposed M6 outperforms the baseline in a number of downstream tasks concerning both single modality and multiple modalities We will continue the pretraining of extremely large models by increasing data to explore the limit of its performance
Try using models to generate summary,it takes about 60s
Must-Reading Tree
Example
Generate MRT to find the research sequence of this paper
Related Papers
Elliott Bennett-Guerrero, Tim H. Veldman,Allan Doctor,Marilyn J. Telen,Thomas L. Ortel, T. Scott Reid, Melissa A. Mulherin,Hongmei Zhu, Raymond D. Buck,Robert M. Califf,Timothy J. McMahon
2007

被引用788 | 浏览

Data Disclaimer
The page data are from open Internet sources, cooperative publishers and automatic analysis results through AI technology. We do not make any commitments and guarantees for the validity, accuracy, correctness, reliability, completeness and timeliness of the page data. If you have any questions, please contact us by email: report@aminer.cn
Chat Paper

要点】:这篇回顾性队列研究探讨了在心脏手术患者中,使用接近储存期末的血液(超过35天)与患者发病率及死亡率之间的潜在联系,发现这类输血并未显著增加患者的住院死亡率和并发症频率,但输血量与不良结果存在剂量依赖性差异。

方法】:研究通过分析2007至2013年昆士兰州健康住院患者数据收集数据库,纳入了接受冠状动脉旁路移植和瓣膜修复手术的患者,采用多变量逻辑回归分析输注的浓缩红细胞(pRBC)年龄(<35天 vs ≥35天)对住院死亡率和发病率的影响。

实验】:共4514名接受心脏手术的患者接受了pRBC输注,其中6.5%的患者接受了储存时间超过35天的pRBC。研究未发现住院死亡率或并发症发生率的差异。输注≥5个单位的pRBC与输注≤4个单位的pRBC相比,住院死亡率、急性肾衰竭、感染和急性心肌梗死的发生率更高。研究中使用的数据集为 Queensland Health Admitted Patient Data Collection database 2007-2013。