CPX-351 for Higher Risk Myelodysplastic Syndrome: Cytarabine and Daunorubicin in Disguise?

Petra MuusTop Scholar,Theo de WitteTop Scholar

The Lancet Haematology（2023）

Leeds Teaching Hosp NHS Trust

Cited 0|Views4

Abstract

Higher-risk myelodysplastic syndrome is a heterogenous disease with a poor prognosis that occurs in older people. 1 Greenberg PL Myelodysplastic syndromes, thy name is heterogeneity. Br J Haematol. 2023; 201: 381-382 Crossref PubMed Scopus (0) Google Scholar Current treatment regimens usually result in a transient and often less than complete response. Only allogeneic haematopoietic stem-cell transplantation (HSCT) can potentially cure a select group of relatively young and fit patients. These patients usually receive remission induction therapy before allogeneic HSCT, but in the absence of well designed, prospective randomised clinical trials, its value remains uncertain. 2 de Witte T Bowen D Robin M et al. Allogeneic hematopoietic stem cell transplantation for MDS and CMML: recommendations from an international expert panel. Blood. 2017; 129: 1753-1762 Crossref PubMed Scopus (220) Google Scholar CPX-351 in higher risk myelodysplastic syndrome and chronic myelomonocytic leukaemia: a multicentre, single-arm, phase 2 studyCPX-351 appears to be active and safe in patients with higher-risk myelodysplastic syndrome and chronic myelomonocytic leukaemia, allowing bridging to allogenic HSCT in most patients. Full-Text PDF

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Hematopoietic Cell Transplantation

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Pretraining has recently greatly promoted the development of natural language processing (NLP)
We show that M6 outperforms the baselines in multimodal downstream tasks, and the large M6 with 10 parameters can reach a better performance
We propose a method called M6 that is able to process information of multiple modalities and perform both single-modal and cross-modal understanding and generation
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