Synthesis and Biological Evaluation of Simplified Ajudazol Derivatives Reveal Potent 5-Lipoxygenase Inhibition and Considerable Apoptotic Activity in Neuroblastoma Cells

Simplified analogues of the myxobacterial polyketide ajudazol were obtained by synthesis and evaluated for their biological activities. Potent simplified 5-lipoxygenase inhibitors were identified. Moreover, strong anti -proliferative and apoptotic activities were observed in brain cancer cell lines at low nano-to micromolar concentrations.