Prognostic Role of Glomerular Electron Microscopy Lesions in IgA Nephropathy: "the Devil is in the Details".

Transmission electron microscopy enables examination of ultrastructural glomerular changes; while this tool has already been applied in IgA nephropathy (IgAN), limited information exists on the prognostic value in this disease. We aimed to systematically investigate ultrastructural lesions and assess their role in predicting the evolution of IgA nephropathy to end-stage kidney disease. A single-center retrospective study was performed on 107 consecutive IgAN patients (median age 42 years, 67