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    • Differential Protein Expression Patterns of HOXA13 and HOXB13 Are Associated with Bladder Cancer Progression.

    Fee-Wai Chin,Huzlinda Hussin,De-Ming Chau,Teng-Aik Ong,Rosna Yunus,Azad Hassan Abdul Razack,Khatijah Yusoff,Soon-Choy Chan,Abhi Veerakumarasivam

    DIAGNOSTICS（2023）SCI 4区SCI 3区

    Univ Putra Malaysia UPM | Univ Malaya | Hosp Kuala Lumpur | Malaysia Genome & Vaccine Inst

    Cited 1|Views24
    Abstract
    Bladder cancer is a common urological cancer and has the highest recurrence rate of any cancer. The aim of our study was to profile and characterize the protein expression of homeobox A13 (HOXA13) and homeobox B13 (HOXB13) genes in Malaysian bladder cancer patients. The protein expression of HOXA13 and HOXB13 in formalin-fixed paraffin-embedded (FFPE) bladder cancer tissues was determined by immunohistochemistry (IHC) analysis. The association between HOXA13/HOXB13 protein expression and demographic/clinicopathological characteristics of the bladder cancer patients was determined by chi-square analysis. Approximately 63.6% of the bladder cancer tissues harbored high HOXA13 expression. High HOXA13 expression was significantly associated with non-muscle invasive bladder cancer, lower tumor grade, higher number of lymph node metastases, and recurrence risk. In contrast, low HOXB13 expression (including those with negative expression) was observed in 71.6% of the bladder cancer tissues analyzed. Low HOXB13 expression was significantly associated with muscle-invasive bladder cancer, higher tumor stage, tumor grade, and metastatic risk. Both HOXA13 and HOXB13 protein expression were found to be associated with bladder tumorigenesis. The putative oncogenic and tumor suppressive roles of HOXA13 and HOXB13, respectively, suggest their potential utility as biomarkers in bladder cancer.
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    biomarker,bladder cancer,HOXA13,HOXB13,immunohistochemistry
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    【要点】：研究揭示了HOXA13和HOXB13蛋白表达模式与膀胱癌进展的关联，并指出它们作为膀胱癌生物标志物的潜在应用价值。
    

    【方法】：通过免疫组化分析（IHC）确定马来西亚膀胱癌患者石蜡包埋福尔马林固定（FFPE）组织中HOXA13和HOXB13的蛋白表达情况，并采用卡方分析评估蛋白表达与患者人口统计和临床病理特征之间的关联。
    

    【实验】：在膀胱癌组织中，63.6%的样本表现出高HOXA13表达，而71.6%的样本表现出低HOXB13表达。研究发现，HOXA13的高表达与低侵袭性膀胱癌、低肿瘤分级、较多的淋巴结转移和复发风险相关，而HOXB13的低表达与高侵袭性膀胱癌、高肿瘤分期、肿瘤分级和转移风险相关。实验使用的数据集为马来西亚膀胱癌患者的FFPE组织样本，并得到了与膀胱癌发生相关的蛋白表达关联结果。