It's Time to Go Glyco in Cell Wall Bioengineering

Tailoring the structure of cellulose, hemicellulose or pectin in plant cell walls can modulate growth, disease resistance, biomass yield and other important agronomic traits. Recent advances in the biosynthesis of microfibrils and matrix polysaccharides force us to re-examine old assumptions about the assembly and functions of cell wall components. The engineering of living or hybrid materials in microorganisms could be adapted to plant biopolymers or to inspire the development of new plant-based composites. High-throughput cellular factories and synthetic biology toolkits could unveil the biological roles and biotechnological potential of the large, unexplored space of carbohydrate-active enzymes. Increasing automation and enhanced carbohydrate detection methods are unlocking new routes to design plant glycans for a sustainable bioeconomy.