APPLICATION OF THE H2FPEF-SCORE TO A GLOBAL CLINICAL TRIAL OF PATIENTS WITH HEART FAILURE WITH PRESERVED EJECTION FRACTION: THE TOPCAT TRIAL

Peder L. Myhre,Muthiah Vaduganathan,Brian Claggett,Carolyn S.P. Lam,Akshay S. Desai,Inder S. Anand,Nancy K. Sweitzer,James C. Fang, Eileen O’Meara,Sanjiv J. Shah,Amil Shah,Eldrin F. Lewis,Jean L. Rouleau,Bertram Pitt, Scott Solomon

Journal of the American College of Cardiology（2019）

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摘要

Diagnostic uncertainties have posed challenges to the conduct of global trials of heart failure with preserved ejection fraction (HFpEF). We applied the H2FPEF-score, a validated diagnostic algorithm for HFpEF, to the TOPCAT trial. The H2FPEF-score (age, BMI, hypertension medication use, atrial

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