The Synthesis and Antimycobacterial Properties of 4-(Substituted Benzylsulfanyl)pyridine-2-carboxamides

4-(Substituted benzylsulfanyl)pyridine-2-carboxamides 6 were synthesized by a three-step synthesis starting from 4-chloropyridine-2-carboxylic acid and substituted benzyl thiols, with the exception of nitroderivatives.The compounds were evaluated for their anti-TB activity against M. tuberculosis, non-tuberculous mycobacteria (M.kansasii and M. avium), and MDR strains of M. tuberculosis.The activities expressed as the minimum inhibitory concentration (MIC) fall into the range of 8-250 µmol/L.The substances exhibited similar activities against both sensitive and resistant strains.