Impact of Coronavirus Disease 2019 (COVID-19) on Healthcare-Associated Infections: an Update and Perspective

Of these 78 patients, 10 COVID-19-suspect inpatients (12.8%) died.A comparison of COVID-19 suspect inpatients who died versus those who survived is listed in Table 1.COVID-19 was confirmed in 17 patients (21.8%), and the causes for mortality included bacterial infections (8 of 10, 80%) and the noninfectious diseases diagnoses included diabetic ketoacidosis (1 of 10, 10%) and acute coronary artery diseases (1 of 10, 10%).Notably, lower mortality was detected among patients who were diagnosed with viral infections [0 of 10 (0%) vs 34 of 68 (50%); P = .004]and patients admitted from the emerging infectious diseases clinic [0 of 10 (0%) vs 29 of 68 (42.6%);P = .01](Table 1).None of healthcare workers (HCWs) in this hospital became infected with SARS-CoV-2 during the study period.By multivariable analysis, a final diagnosis of bacterial infection (aOR, 13.7; 95% confidence interval [CI], 1.45-89.5;P < .001),initial evaluation in the emergency department (aOR, 10.8; 95% CI = 3.6-59.5;P = .001),and delayed time to admission (>60 minutes from emergency department or >120 minutes from outpatient departments) were associated with mortality in this unit (aOR, 7.7; 95% CI, 2.44-69.7;P = .005).Several processes of care identified as issues among patients admitted to the unit included delays in laboratory procurements (23 of 78, 29.5%), time to admission (49 of 78, 39.7%), and deployment of critical medical measures such as IV fluid and antibiotic administration (4 of 78, 5.1%).We report a high mortality rate in a COVID-19-suspect unit in a Thai hospital.This mortality rate was 2 times higher than that of medical patients with comparable severity of illness admitted during the same period.This difference was related to several suboptimal processes in the care of patients requiring specialized medical care (eg, acute coronary artery disease, diabetic ketoacidosis, bacterial infections).In a previous report from Thailand, HCWs were overwhelmed with fear and anxiety regarding COVID-19. 5Such emotions affect patient care when HCWs are not willing to accept new patients or see admitted patients during epidemics, which may compromise patient safety. 5 HCWs may be swayed by anecdotal stories that may impair clinical decision making.Anxiety and fear of contagion, despite the evidence of the effectiveness of personal protective equipment, may alter care. 5 Despite the limitations of sample size and retrospective design, our study calls for a better emerging infectious disease preparedness plans in hospitals to incorporate the care for patients admitted to the COVID-19-suspect unit who may need special care.They should receive care without delay at the initial evaluation site, particularly the emergency department, before transfer to the COVID-19-suspect unit.Mechanisms for monitoring the processes of care among these patients are critical for their survival.Additional studies to evaluate strategies to improve the quality of care, as well as patient safety during epidemics, are needed.