Gut microbiome interventions in regenerative medicine

Elsevier eBooks(2023)

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摘要
The human microbiota comprises trillions of microorganisms, and both humans and microbes are influenced by their continuous coevolutionary intimate history. The gastrointestinal tract contains the most diverse and dense microbiome in the human body, and its composition can be affected by intestinal microenvironmental parameters such as pH, oxygen levels, nutrient availability, water activity, and temperature. The intestinal microbiome is crucial for the development, maturation, and modulation of the innate and adaptive immune systems and for neurological development. The human intestine acts as a “bioreactor” into which the microbial community is inserted. In this environment, substrates are transformed into products, and the different biological agents act in a complex communication network. This chapter describes various aspects of epigenetics and microbiota as well as the effects of diet and immunomodulation to assist the understanding of gut microbiome interventions in regenerative medicine.
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关键词
microbiome interventions,gut microbiome,regenerative medicine
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