Treating Uterine Synechiae with Human Amniotic Membrane Graft

Objective: To determine if placement of a human amniotic membrane graft at the time of hysteroscopic intrauterine adhesiolysis will promote regeneration of the endometrium in women with secondary amenorrhea and infertility.This case-series evaluated the use of human amniotic membrane graft in women with secondary amenorrhea and who had a desire for future fertility.Results: Five women received the amniotic membrane graft between 2015-2019.Four of the five women had secondary amenorrhea and one had scanty periods prior to the surgery (post suction and evacuation procedure due to spontaneous miscarriage), and all of the women achieved menstruation post-operatively.Two of them achieved pregnancy. Conclusion:This procedure may provide an alternative treatment option for patients with uterine synechiae who desire future menses and pregnancy.