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Synthesis of Hybrid Isoxazole‐triazole Compounds As Potential Antiproliferative Agents

Asian journal of organic chemistry(2023)

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摘要
An efficient route for the synthesis of a series of new hybrid isoxazole-triazole compounds in high yields and excellent regioselectivity starting from either 2-aryl-1,1-dichlorocyclopropanes or N-hydroxybenzimidoyl chlorides was developed. The synthesized isoxazole-triazole hybrids were evaluated for their biological activity.
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关键词
isoxazole-triazole hybrid compounds,cyclopropane nitrosation,nitrile oxide synthesis,iodination,Sonogashira ethynylation sequence,CuAAC reaction
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