Monoallelic KRAS (G13C) Mutation Triggers Dysregulated Expansion in Induced Pluripotent Stem Cell-Derived Hematopoietic Progenitor Cells

Huan-Ting Lin,Masatoshi Takagi,Kenji Kubara,Kazuto Yamazaki, Fumiko Michikawa,Takashi Okumura,Takuya Naruto,Tomohiro Morio,Koji Miyazaki,Hideki Taniguchi,Makoto Otsu

Stem Cell Research & Therapy（2024）

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关键词

Human-induced pluripotent stem cells,Hematopoietic system,Stem cells,Lymphoproliferative disorders,KRAS protein,Oncogene,Apoptosis regulatory proteins,Cell cycle,Inhibitors,Biological models

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