Smart Chitosan-Based Microgels for Enhanced Photothermal-Assisted Antibacterial Activity.
International journal of biological macromolecules(2023)
Abstract
During recent years, antibiotic-resistant bacteria have rapidly emerged owing to the irrational use of antibiotics, rendering a global problem. Currently, few studies introduce customized antibacterial nanoplatforms to overcome antibiotic-resistance according to specific characteristic of bacteria, rather than abuse of antibiotic. Herein, with regard to personalized antibacterial nanoplatform, we design a novel antibiotic delivery nanocarrier composed of polyaniline-grafted-chitosan, presenting pH-responsive, conductive, photothermal, and biodegradable properties. After treatment with divalent anion (SO42-), the negatively charged nanocarriers are obtained for improving the loading efficacy of cationic vancomycin. Meanwhile, the controlled vancomycin release is achieved by lysozyme-triggered degradation of the nanocarrier. With the assistance of photothermal effect, the photothermal-assisted antibacterial effect of the nanocarriers have been effectively enhanced rather than that of a single antibacterial effect of vancomycin. Owing to the low heat resistance of Escherichia coli, photothermal effect can break the antibiotic-resistant bacteria membrane to render the convenient antibiotic entry, leading to the improved antibacterial efficacy. Therefore, the customization of a photothermal-assisted antibacterial on account of the characteristic of specific bacteria can definitely expand our arsenal for enhancing the antibacterial effect against antibiotic-resistant bacteria.
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Key words
Chitosan-polyaniline microgels,Stimuli-responsive behavior,Lysozyme-triggered degradation,Controlled vancomycin release,Photothermal-assisted antibacterial activity
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