Modulation of Neuroimmune and Epithelial Dysregulation in Patients With Moderate to Severe Prurigo Nodularis Treated With Nemolizumab.

Junwen Deng,Viviane Liao,Varsha Parthasarathy,Hannah L Cornman,Anusha Kambala,Madan M Kwatra,Sonja Ständer,Christophe Piketty, Prasad Chaskar,Jayendra Kumar Krishnaswamy,Valerie Julia,Shawn G Kwatra

JAMA dermatology（2023）

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摘要

In this cohort study, differences between nemolizumab and placebo groups included modulation of inflammatory signaling, neural development, and epithelial differentiation, suggesting a promising potential approach for clinical management of PN.

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关键词

severe prurigo nodularis,neuroimmune,nemolizumab,epithelial dysregulation

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