Modulation of Taxane Binding to Tubulin Curved and Straight Conformations by Systematic 3'N Modification Provides for Improved Microtubule Binding, Persistent Cytotoxicity and in Vivo Potency.
European journal of medicinal chemistry（2023）
Key words
Taxane,Microtubule,Tubulin,Curved conformation,Straight conformation,Persistent cytotoxicity
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