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    • Synthesis and Meta-analysis of 3 Randomized Trials Conducted in Burkina Faso, Ghana, and Uganda Comparing the Effects of Point-of-Care Tests and Diagnostic Algorithms Versus Routine Care on Antibiotic Prescriptions and Clinical Outcomes in Ambulatory Patients <18 Years of Age with Acute Febrile Illness.

    Piero Olliaro,Juvenal Nkeramahame,Philip Horgan,Halidou Tinto,Francois Kiemde,Rita Baiden,Alexander Adjei,James Kapisi,Heidi Hopkins,Olawale Salami,Catrin E. Moore,Sabine Dittrich,Stephan Weber,Stefano Ongarello

    Clinical Infectious Diseases（2023）SCI 1区

    Pandem Sci Inst | FIND | Inst Rech Sci Sante | INDEPTH Network | Dodowa Hlth Res Ctr | Infect Dis Res Collaborat | London Sch Hyg & Trop Med | Univ Oxford

    Cited 1|Views23
    Abstract
    This meta-analysis included 3 randomized trials conducted in sub-Saharan Africa comparing the effects of point-of-care tests and diagnostic algorithms versus routine care on antibiotic prescriptions and clinical outcomes in ambulatory patients presenting at outpatient facilities with acute uncomplicated febrile illness.
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    antibiotic prescriptions,point-of-care diagnostic tests,febrile illnesses,diagnostic algorithms
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    • Pretraining has recently greatly promoted the development of natural language processing (NLP)
    • We show that M6 outperforms the baselines in multimodal downstream tasks, and the large M6 with 10 parameters can reach a better performance
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    【要点】：本研究通过合成和分析在布基纳法索、加纳和乌干达进行的3项随机试验，探讨了在18岁以下门诊急性发热病患中，床旁检测和诊断算法与常规护理相比，对抗生素处方和临床结果的影响，发现使用床旁检测和诊断算法能减少抗生素的不必要使用。
    

    【方法】：论文采用荟萃分析的方法，整合了三项在撒哈拉以南非洲地区进行的随机对照试验数据。
    

    【实验】：研究分析了涉及床旁检测和诊断算法与常规医疗护理对比的三项试验，具体数据集名称在文中未提及，但试验结果显示，这些方法显著降低了无必要抗生素的处方率，并可能改善了临床结果。